Viral antigen-specific CD8+ T-cell responses are impaired in multiple myeloma
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چکیده
منابع مشابه
Antigen-specific T-cell Responses with Antigen-expression and Immunoparalysis in Multiple Myeloma
Running title: Antigen-expression and specific T-cell responses in Myeloma th framework program OVER-MyR. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Despite a variety of therapeutical approaches including high dose chemotherapy with subsequent autologous stem cell transplantation, Multiple Myeloma remains an almost incurable disease. Ne...
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PURPOSE Cancer testis antigens (CTA) are immunotherapeutical targets aberrantly expressed on multiple myeloma cells, especially at later stages, when a concomitant immunoparesis hampers vaccination approaches. EXPERIMENTAL DESIGN We assessed the expression of the multiple myeloma antigen HM1.24 (reported present in all malignant plasma cells) and the CTAs MAGE-A2/A3 and NY-ESO-1 (aberrantly e...
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Purpose: Cancer testis antigens (CTA) are immunotherapeutical targets aberrantly expressed on multiple myeloma cells, especially at later stages, when a concomitant immunoparesis hampers vaccination approaches. Experimental Design: We assessed the expression of the multiple myeloma antigen HM1.24 (reported present in all malignant plasma cells) and the CTAs MAGE-A2/A3 and NYESO-1 (aberrantly ex...
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The Rockefeller University Press $30.00 J. Exp. Med. 2014 Vol. 211 No. 2 297-311 www.jem.org/cgi/doi/10.1084/jem.20130902 297 T cell–specific co-stimulation blockade is an attractive alternative to traditional immunosuppression to mitigate unwanted immune responses during transplantation and autoimmunity. Owing to the limited tissue distribution of its targets, T cell co-stimulation blockade of...
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Multiple myeloma (MM) is the second most common hematologic malignancy with an incidence of 15 000 new cases per year in the United States alone, and is characterized by the proliferation of a malignant plasma cell clone within the human bone marrow (BM). The expansion of neoplastic plasma cells producing a monoclonal immunoglobulin typically results in BM failure with anemia, skeletal involvem...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2003
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2003.04375.x